Intravenous dexmedetomidine infusion in adult patients undergoing open nephrolithotomy: Effects on intraoperative hemodynamics and blood loss; a randomized controlled trial

Rashwan, Doaa A.; Rashwan, Samaa A.; Talaat, Nashwa N.

doi:10.1016/j.egja.2015.03.007

Intravenous dexmedetomidine infusion in adult patients undergoing open nephrolithotomy: Effects on intraoperative hemodynamics and blood loss; a randomized controlled trial

Authors

10.1016/j.egja.2015.03.007

Abstract

Objective
The aim of this study was to evaluate the effect of intravenous infusion of dexmedetomidine on intraoperative hemodynamics and blood loss during open nephrolithotomy under general anesthesia in adult patients.
Method
50 male and female patients, ASA physical status I and II aged 20–60 years old scheduled for open nephrolithotomy under general anesthesia were randomly allocated into two equal groups:
Results
Intraoperative heart rate and systolic and diastolic arterial blood pressure were statistically significantly lower in group D than in group P. The intraoperative blood volume lost was statistically significantly higher in group P than in group D. A number of the transfused units of PRBCs, intraoperative and postoperative hemoglobin % and hematocrit concentration were statistically significantly lower in group P than in group D.
Conclusion
Dexmedetomidine infusion in patients undergoing open nephrolithotomy under general anesthesia was associated with intraoperative hemodynamic stability, which decreases intraoperative blood loss and the need for intraoperative blood transfusion.