Ultra-low-dose naloxone added to fentanyl and lidocaine for peribulbar anesthesia: A randomized controlled trial

Purpose
Purpose was to evaluate the quality of the block and the duration of postoperative analgesia when ultra-low-dose of naloxone added to fentanyl and lidocaine for peribulbar anesthesia.
Methods
Sixty adult patients of both sexes, ASA I and II scheduled for open globe cataract surgery in the Ophthalmology Department Tanta University Hospital were included in this randomized prospective clinical trial.
Results
The time to first rescue analgesic was significantly longer in group II (7.73 ± 0.98) than group I (4.30 ± 0.47). The IOP was increased significantly at 2 min post-injection then, it became insignificant at 10 min postinjection compared to the preinjection values in both groups. There were few minor complications with no significant difference between groups.
Conclusion
Addition of ultra-low-dose naloxone to fentanyl and lidocaine for peribulbar anesthesia prolongs the duration of postoperative analgesia without increasing the adverse effects.