Donor gender effect on graft function in adult Egyptian patients undergoing living donor liver transplantation: A single centre study

Salah, Manar; Montasser, Iman F.; El-Gendy, Hanaa A.; Korraa, Alaa A.; Elewa, Gamal M.; Dabbous, Hany; Abdelrahman, Mostafa; Goda, Mohammed Hisham; Bahaa, Mohamed M.; El Meteini, Mahmoud; Labib, Heba A.

doi:TEJA-2022-0004

Donor gender effect on graft function in adult Egyptian patients undergoing living donor liver transplantation: A single centre study

Authors

TEJA-2022-0004

Abstract

Background
The aim of this study was to evaluate the role of donor-to-recipient gender match in the setting of living donor liver transplant as a potential predictor of graft and recipient survivals.
Methods
In this retrospective, single-center study, the data of 342 adult primary liver transplants were analyzed. The donor and recipient’s characters, intraoperative data, and postoperative outcomes were recorded.
Results
The donor-recipient gender matched patients had significantly better graft survival outcomes than the gender mismatched ones. The 2-year graft survival probability was 95.7% in the matched group compared to 89.1% in the mismatched one (p = 0.026). A female donor-male recipient combination (87.3%) showed worse 2-years graft survival than a male-to-male transplant (94.8%), while it gave better graft survival than male to female (61.3%). The estimated relative risk of graft rejection was 5.91 times significantly higher in a male–female combination than in a male-to-male one (Hazard ratio = 5.91, 95% CI = 1.34–26.11).
Conclusion
This study suggests that donor-recipient gender mismatch is associated with poor liver graft survival outcomes, with higher risk of graft rejection in male-female transplants than in male-to-male ones. Though, further larger studies including multiple datasets are needed, with adjustments for various graft, donor, and recipient factors to reach solid evidence.

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