Evaluation of serum taurine as a prognostic marker for graft function in adult Egyptian patients undergoing living donor liver transplant

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Abstract

: Taurine has been investigated as a potential screening marker for early diagnosis of hepatocellular carcinoma and other liver diseases. This study was conducted to evaluate serum taurine as a potential prognostic marker for graft function in Egyptian patients undergoing living donor liver transplant.
: A prospective cohort study was conducted during August 2019 to May 2020. We measured serum taurine levels using high-performance liquid chromatography in patients with end-stage liver disease who were candidates for living donor liver transplant before transplant, then on the 7th, 14th, and 30th day post-transplant. Patients were followed up to detect graft dysfunction, Seventh Day Syndrome, and the 30-day mortality.
: Sixty patients were enrolled in this study. Preoperative serum taurine levels did not correlate significantly with liver function tests, and its predictive performance for primary graft dysfunction and 30-day mortality was poor (area under curve [AUC] = 0.662; p = 0.038 and AUC = 0.642; p = 0.202, respectively). Serum taurine level at the 7th post-transplant day had good diagnostic performance for primary graft dysfunction (AUC = 0.827; p < 0.001) and good predictive performance for 30-day mortality (AUC = 0.888; p < 0.001). Only two patients with taurine level <30 µmL developed Seventh Day Syndrome.
: Preoperative serum taurine level had poor prognostic value for primary graft dysfunction or 30-day mortality. However, its serum level at the 7th day post-transplant had good diagnostic value for primary graft dysfunction and good prognostic value for 30-day mortality. Future research should investigate the potential predictive value of taurine levels regarding primary graft dysfunction and Seventh Day Syndrome.

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Egyptian Journal of Anaesthesia
Volume 36, Issue 1
January 2020
Pages 273-281

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